MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

Abstract Background Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the antitumor mechanism of MASTL targeting in cancer cells is still unclear.Methods MASTL expression was evaluated by using br

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Different distribution patterns between putative ercoid mycorrhizal and other fungal assemblages in roots of Rhododendron decorum in the Southwest of China.

Fungal diversity within plant roots is affected by several factors such as dispersal limitation, habitat filtering, and plant host preference.Given the differences in life style between symbiotic and non-symbiotic fungi, the main factors affecting these two groups of fungi may be different.We assessed the diversity of root associated fungi of Rhodo

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Patient, family, and community factors associated with medication adherence among people with hypertension or diabetes: A cross-sectional analysis

Background: While suboptimal medication adherence remains an obstacle to the management of hypertension and diabetes in China, few studies have investigated associated factors with medication adherence on different dimensions simultaneously.Objective: To systematically examine associated patient, family, and community factors with suboptimal medica

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Electrostatic Repulsion of Dust from Planetary Surfaces

Surfaces of planetary bodies can have strong electric fields, subjecting conductive grains to repulsive electrostatic forces.This has been proposed as a mechanism to eject grains from Infrared Thermometers the ground.To quantify this process, we study millimeter-sized basalt aggregates consisting of micrometer constituents exposed to an electric fi

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